Ask a Doctor: Do Stem Cell Face Creams Really Work?

A facial plastic surgeon tells us the truth behind the stem cell face cream marketing hype.

stem cell face creamFace cream illustration via Shutterstock

If you’ve been to the beauty counter lately or up late enough to see the infomercials, the latest in skin creams supposedly have “stem cell technology”. But do they really work? According to the American Society of Aesthetic Plastic Surgery, there were more than nine million cosmetic procedures in the United States last year, at the cost of $10 billion. Yes, billion. It’s a big business, and everyone wants in.

Over the past few years, more and more facial creams have been introduced into the U.S. markets claiming to minimize the appearance of wrinkles and to slow down, even reverse, the course of aging. Under the guise of terms like “scientifically engineered”, these creams claim to harness the power of stem cells or stem cell extracts.

Stem cells are cells within the body capable of regenerating into new tissue. Stem cells can be found in various places within the body like the bone marrow or within the deeper layers of the skin. They can regenerate themselves and differentiate into any type of tissue (bone, cartilage, nerve, muscle, etc.) that is needed depending on their surrounding environment. Stem cells hold some promise in areas of wound healing, tissue engineering, and some neurological disorders.

Some products claim their active ingredient is a plant stem cell (apple seems to be the most popular), while others state there are no stem cells, but utilize stem cell extracts as their active ingredient. The overall stated goal of these products is to stimulate the amount of collagen formation and other peptides within the skin to improve its elasticity and texture, calling them “cosmeceuticals”. That term was coined by the industry as a way of giving the impression that the cosmetic has a drug-like benefit. It is just the marketing department’s way of giving you the impression that you are getting the most advanced treatment and biggest bang for your buck.

The term cosmeceuticals is not recognized by the U.S. Food and Drug Administration and thus not subject to its regulatory scope. What this means is that not one of these products are required to prove the validity of the science it preaches for it products. To date, none of these companies have published any significant data in the literature that proves their effectiveness. Furthermore, no stem cells could even survive long-term embedded in a cream, let alone be guaranteed to work on all individuals (your body would be more likely to reject foreign cells).

Stem cells are also being used for facial rejuvenation (not in a cream) by harvesting stem cells within your own body. Performed by a qualified surgeon, the cells are processed and re-injected into your face. The results of these treatments seem promising. But having an individual get benefits simply by applying a cocktail of ingredients and apple stem cells on their skin remains to be scientifically proven.

The bottom line is that there is no conclusive scientific data that absorbing stem cell extracts from a cream can really reverse the aging process. My advice is that a good cream is a good cream. But if the advertising seems to good to be true, it most likely is. Buyer beware.

—Dr. Waleed Ezzat

Waleed Ezzat, MD is a facial reconstructive surgeon at the Boston Medical Center. His expertise is in aesthetic facial plastic surgery, as well as advanced facial reconstructive surgery. He serves on national committees for the American Academy of Facial Plastic and Reconstructive Surgery and lectures on facial reconstructive surgery at the regional and national levels.

  • Roxana Pais

    My experience has been, that, yes apple technology works. specially, swiss phylo extract base products, not just in one face, for me has been a life saver as well. Dr? by accident I came around this product at target, even thought the night cream has been discontinue, for some reason. Swiss phylo pant technology, does work.


  • infertilemyrtle

    Oh yeah. These apple stem cells work. Not only does it help your skin, but it makes hair grow. My eyebrows and eyelashes thickened up incredibly too. I was pleasantly surprised.

  • KSV

    I am disturbed that you wrote this article without ever trying the stem cell products. i want to know whether it works, not whether manufacturers are required to show studies.

  • miss_willows

    The only people saying plant stem cells are proven to work are people with something to sell.

    • Maybe?

      That goes for over 99% of the health and beauty market… all the way down to pharmaceuticals.

      Look up the studies on the Flu vaccine and elderberry syrup as just one example. It’s plain to see that anyone selling health or beauty has an interest in pushing it, including doctors, who make big bucks pushing pharmaceuticals.

      You want less wrinkles, lose weight or get rid of diabetes? Try eating correctly and your health issues will vanish for the most part.

  • Greg Testa

    Well, I used a free sample of human stem cell serum on a scar on my nose. It’s been there for 6 months and nearly disappeared until I ran out of the sample. I was a sceptic but it really worked like I’ve never seen a cream work before!

    • Joe

      did you even read the article ? It talks about PLANT stem cells

      • Greg Testa

        Yes I did

    • Faeth DeHart

      What was the name of that serum? tks

  • Dave Sensei

    Facial creams should remove scars and provide quick benefits to your skin, putting Neosporin or Vaseline on your face would do that. What this article is saying is that cosmeceuticals are not regulated by the FDA and they do not have to scientifically back up their claims.

    If we were to scientifically test adding if stem cells from apples to a facial cream adds additional benefits we would have to have it tested against the exact same cream that lacks the stem cells and have a handful of controls to make the resulting data reliable. If you like to read scientific articles where such experiments are performed, you should look in a scholarly, peer-edited journal. However, they are dry and painful to read. Also, the idea of packing living cells into a cream, and finding a way to keep them alive in a tube on a shelf, and have them effect an organism from a different biological kingdom sounds like something that would take millions of dollars to research and end up at a dead end, not working because duh.

    Of course the creams work, they wouldn’t be a successful way to make money if they didn’t work. What’s a farce is their claims at WHY they work, but they are a cosmeceutical company, which are not regulated by the FDA and they are not legally responsible to scientifically back up their claims. They have the right to make claims that stem cells will fix your face because someone in their marketing staff looked up what stem cells were on wikipedia and thought “Hey, what if we put it in a cream? Actually, I don’t have to experiment at all, let’s just put it in our cream because it kinda makes sense that it might make skin youngerish and that kinda claim on a bottle can make it sell better.”

  • Luxes Vernon

    Do stem cell face creams work? Yes, thankyou. The results are blatantly obvious. Anyway, I’m using Lumavera. or The eye cream is phenominal and when it comes to plant based stem cell molecular technology and virgin botanical ingredients I have yet to find something superior. Super antioxidants, anti-ox my way! Cheerio!